Accession Number : AD1023944


Title :   Heterotopic Ossification Following Extremity Blast Amputation: An Animal Model in the Sprague Dawley Rat


Descriptive Note : Technical Report,30 Sep 2010,31 Dec 2015


Corporate Author : Medical University of South Carolina Charleston United States


Personal Author(s) : Pellegrini,Vincent Jr D


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1023944.pdf


Report Date : 01 Mar 2016


Pagination or Media Count : 55


Abstract : Prior phase I protocols demonstrated water and the hind limb as the preferred medium and location in the animal model. Phase II demonstrated increased tissue damage from pulsed lavage, and a beneficial effect from amputation above the zone of blast injury. Phase III was designed to investigate effects of nonsteroidal anti-inflammatory (NSAID) medication and external beam radiation on development of HO; prior studies served as the control group in order to limit animal numbers.


Descriptors :   osteogenesis , blast injuries , wounds and injuries , Amputation , orthopedic surgical procedures , osteoblasts , animal experimentation , rats


Subject Categories : Medicine and Medical Research
      Weapons Effects(biological)


Distribution Statement : APPROVED FOR PUBLIC RELEASE