Accession Number : AD1023911

Title :   Dual-Modulation, Dual-Wavelength, Optical Polarimetry System for Glucose Monitoring

Descriptive Note : OSTP Journal Article

Corporate Author : Texas A&M University College Station United States

Personal Author(s) : Yu,Zhen Fang ; Pirnstill,Casey W ; Cote,Gerard L

Full Text :

Report Date : 26 Aug 2016

Pagination or Media Count : 25

Abstract : Using optical polarimetry for probing aqueous humor glucose concentrations has the potential for ascertaining blood glucose noninvasively. One major limiting factor for the realization of polarimetry is time-varying corneal birefringence due to motion artifact. To enhance the speed of the polarimetry system and provide real time closed-loop feedback at two wavelengths that can help overcome the time-varying birefringence, a dual-modulation system was designed, built and tested. This new system utilized laser intensity and polarization modulation to increase the frequency. This configuration also reduced the system complexity by reducing the number of detectors from two to one. In this study, the high speed technique was developed and in vitro phantom studies were performed with and without motion. The glucose concentration ranged of 0-600 mg/dl and the glucose measurements demonstrated the sensitivity and accuracy of the system to within 10 mg/dl without motion and within 14 mg/dl with motion. Our feedback control systems took less than 10 ms to reach stabilization, which is adequately fast to eliminate the effect of time-varying birefringence. The results indicate that this new optical polarimetric approach has improved the speed and reduced the complexity, showing the potential for it to be used for non-invasive glucose measurements.

Descriptors :   glucose , polarimetry , Birefringence , Modulation , MAGNESIUM , biomedical technology , measuring instruments

Subject Categories : Optics
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE