Accession Number : AD1021670


Title :   Molecular Signatures of Chronic Pain Subtypes


Descriptive Note : Technical Report,13 Dec 2010,12 Dec 2014


Corporate Author : Duke University Durham United States


Personal Author(s) : Shaw,Andrew D ; Buchheit,Thomas ; Van de Ven,Thomas


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1021670.pdf


Report Date : 01 Mar 2015


Pagination or Media Count : 128


Abstract : This project was a biomarker discovery and novel analgesic pathway discovery program focusing on the causes of persistent pain after traumatic amputation in the combat setting. During this project we have: 1) maintained the necessary regulatory approval at WRNMMC and Duke University. We have: 1) obtained and maintained documents for approval by MRMC; 2) completed patient enrollment at 124 patients; 3) maintained our interactive, secure web based data collection system; 4) populated our biorepository at Duke with bioresource collected from 124 patients enrolled at WRNMMC; 5) conducted further on-site visits and investigator meetings at WRNMMC; 6) Received and analysed all data from whole exome sequencing, gene expression, DNA methylation, miRNA, proteomic and metabolomic analysis 7) and begun follow up work on these putative pain biomarkers. We have published three papers, have submitted another and have two more in process. We have achieved four major goals: 1) Defined the clinical nature and incidence of chronic pain subtypes in traumatic military amputees 2) Demonstrated the utility of a diagnostic post-amputation pain adjudication algorithm 3) Found that regional anesthesia catheter placement is associated with reduced chronic neuropathic pain in amputees 4) 4. Discovered two novel nociceptive pathways that may serve both as biomarkers of pain and novel analgesic targets and we have received follow-up funding to further study these pathways.


Descriptors :   pain , biological markers , traumatic amputation , algorithms , military personnel , diagnosis (medicine) , ANESTHESIA , inflammation , genome , metabolomics , CATHETERS


Distribution Statement : APPROVED FOR PUBLIC RELEASE