Accession Number : AD1021620


Title :   Bacterial Genome Engineering and Synthetic Biology: Combating Pathogens


Descriptive Note : OSTP Journal Article


Corporate Author : USAMRIID Frederick United States


Personal Author(s) : Moore, Richard T


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1021620.pdf


Report Date : 04 Nov 2016


Pagination or Media Count : 27


Abstract : The emergence and prevalence of multidrug resistant (MDR) pathogenic bacteria poses a serious threat to human and animal health globally. Nosocomial infections and common ailments such as pneumonia, wound, urinary tract, and bloodstream infections are becoming more challenging to treat due to the rapid spread of MDR pathogenic bacteria. According to recent reports by World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC), there is an unprecedented increase in the occurrence of MDR infections worldwide. The rise in these infections has generated an economic strain worldwide, prompting the WHO to endorse a global action plan to improve awareness and understanding of antimicrobial resistance. This health crisis necessitates an immediate action to target the underlying mechanisms of drug resistance in bacteria.


Descriptors :   synthetic biology , DRUG RESISTANCE , pathogenesis , Virulence , BIOMOLECULES , vaccines , strains (biology) , BACTERIAL INFECTIONS


Subject Categories : Genetic Engineering and Molecular Biology
      Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE