Accession Number : AD1020613

Title :   A Cell-Based Approach to Early Pancreatic Cancer Detection

Descriptive Note : Technical Report,30 Sep 2015,29 Sep 2016

Corporate Author : Trustees of the University of Pennsylvania Philadelphia United States

Personal Author(s) : Stanger,Ben Z

Full Text :

Report Date : 01 Oct 2016

Pagination or Media Count : 12

Abstract : During this reporting period, we succeeded in building a device (TEMPO) that can enrich circulating pancreatic tumor cells from mouse blood by depleting the sample of white blood cells (WBCs). Furthermore, the RNA profile of these cells can be assessed by fluorescence in situ hybridization (FISH) and visualized on the same device. Using the device, this entire process can be conducted in a matter of hours without specialized equipment and a standard fluorescent microscope. These studies set the state for further experiments with clinical samples from pancreatic cancer patients.

Descriptors :   detection , Pancreatic diseases , TUMOR CELL LINE , mice , LEUKOCYTES , fluorescence , blood cells , neoplasms

Distribution Statement : APPROVED FOR PUBLIC RELEASE