Accession Number : AD1020613


Title :   A Cell-Based Approach to Early Pancreatic Cancer Detection


Descriptive Note : Technical Report,30 Sep 2015,29 Sep 2016


Corporate Author : Trustees of the University of Pennsylvania Philadelphia United States


Personal Author(s) : Stanger,Ben Z


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1020613.pdf


Report Date : 01 Oct 2016


Pagination or Media Count : 12


Abstract : During this reporting period, we succeeded in building a device (TEMPO) that can enrich circulating pancreatic tumor cells from mouse blood by depleting the sample of white blood cells (WBCs). Furthermore, the RNA profile of these cells can be assessed by fluorescence in situ hybridization (FISH) and visualized on the same device. Using the device, this entire process can be conducted in a matter of hours without specialized equipment and a standard fluorescent microscope. These studies set the state for further experiments with clinical samples from pancreatic cancer patients.


Descriptors :   detection , Pancreatic diseases , TUMOR CELL LINE , mice , LEUKOCYTES , fluorescence , blood cells , neoplasms


Distribution Statement : APPROVED FOR PUBLIC RELEASE