Accession Number : AD1020548


Title :   Investigating the Regulation and Potential Role of Nonhypoxic Hypoxia Inducible Factor 1 (HIF 1) in Aromatase Inhibitor Resistant Breast Cancer


Descriptive Note : Technical Report,15 Sep 2011,14 Sep 2015


Corporate Author : University of Maryland, Baltimore Baltimore United States


Personal Author(s) : Kazi,Armina A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1020548.pdf


Report Date : 01 Dec 2015


Pagination or Media Count : 75


Abstract : This research aims to understand the factors and molecular mechanisms involved in drug-resistant breast cancer, specifically aromatase inhibitor resistant breast cancer. Although aromatase inhibitors (AIs; i.e., letrozole) have been shown to be highly effective in treating estrogen receptor positive (ER+) breast cancer, a significant percentage of patients either do not respond to AIs or become resistant to them. Previous studies suggest that resistance to AIs involves a switch from dependence on ER signaling to dependence on growth factor-mediated pathways, such as human epidermal growth factor receptor-2 (HER2). The mechanism by which HER2 is involved in AI resistance remains mostly unclear. It is, therefore, important to elucidate theHER2-mediated pathway that contributes to AI resistance, and to identify other relevant factors involved that can be used as biomarkers of AI resistance or targets for therapy.


Descriptors :   breast cancer , Resistance(Biology) , stem cells , therapeutics , neoplasms , metastasis , proteins


Distribution Statement : APPROVED FOR PUBLIC RELEASE