Accession Number : AD1019338


Title :   Crosstalk between mTORC1 and cAMP Signaling


Descriptive Note : Technical Report,01 Jul 2013,30 Jun 2016


Corporate Author : CALIFORNIA UNIV SAN DIEGO LA JOLLA LA JOLLA United States


Personal Author(s) : Guan,Kun-Liang


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1019338.pdf


Report Date : 01 Sep 2016


Pagination or Media Count : 32


Abstract : Mutation in TSC1 and TSC2 genes are responsible for tuberous sclerosis complex (TSC). The major function of TSC1/2 is to inhibit mTORC1, thus, uncontrolled mTORC1 activation is the key for TSC. This project studies the molecular mechanisms of negative regulation of mTORC1. We have shown that mTORC1 is potently inhibited by hormones that stimulating cAMP, which acts through protein kinase A (PKA) to inhibit mTORC1. We observed the mTORC1 is inhibited by osmotic stress and possible role of the NLK kinase in mTORC1. We also discovered that different amino acids stimulate mTORC1 by different mechanisms.


Descriptors :   Mutations , amino acids , growth factors , proteins , inhibition , phosphorylation , genes , hormones


Distribution Statement : APPROVED FOR PUBLIC RELEASE