Accession Number : AD1018340


Title :   Control of Cellular Structural Networks Through Unstructured Protein Domains


Descriptive Note : Technical Report,01 Oct 2009,30 Oct 2015


Corporate Author : University of California - Berkeley Berkeley United States


Personal Author(s) : Kumar,Sanjay


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1018340.pdf


Report Date : 01 Jul 2016


Pagination or Media Count : 15


Abstract : The goal of this project is to implement a research program in cellular bioengineering that focuses on hierarchical structural and mechanicalnetworks in cells. The research plan seeks to determine the role of molecularscalesteric forces on the assembly, mechanics, and cellstructural contributions of UPDs. There are three aims: (1) To determine the quantitative relationship between chain phosphorylation andsteric repulsive properties of UPDs in vitro; (2) To experimentally test the hypothesis that altering neurofilament UPD phosphorylation altersmorphology, mechanics, and neurogenesis in neural stem cells; (3) To develop and use multiscale computational modeling approaches torelate cytoskeletal protein phosphorylation to cellular mechanical properties.


Descriptors :   proteins , networks , cells(biology) , molecules , peptides , phosphorylation , bioengineering


Distribution Statement : APPROVED FOR PUBLIC RELEASE