Accession Number : AD1018322


Title :   IMPACT: Imaging and Molecular Markers for Patients with Lung Cancer: Approaches with Molecular Targets, Complementary/Innovative Treatments, and Therapeutic Modalities


Descriptive Note : Technical Report,01 Feb 2005,31 Jan 2016


Corporate Author : The University of Texas M.D. Anderson Cancer Center Houston United States


Personal Author(s) : Simon,George


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1018322.pdf


Report Date : 01 Apr 2016


Pagination or Media Count : 88


Abstract : The projects in this proposal specifically target several signal transduction pathways known to be critical for NSCLC pathogenesis including the EGFR pathway and the more downstream ras/raf/Mek/ERK pathway. These projects combine targeted approaches using molecular and imaging techniques to validate activity against a target and monitor response using imaging modalities specific to the receptor using either small molecules or targeted peptide approaches. This document serves as the final report for this grant, and details the results of the clinical trial that was the central focus of the last active project (Project 2) as well as provides summaries of the final reports for each of the other projects and cores that completed aims in previous years.


Descriptors :   lung cancer , biological markers , DIAGNOSTIC IMAGING , targets , therapeutics , neoplasms , drug therapy , inhibitors


Distribution Statement : APPROVED FOR PUBLIC RELEASE