Accession Number : AD1017782


Title :   Epilepsy and the Wnt Signaling Pathway


Descriptive Note : Technical Report,01 Jun 2012,03 May 2013


Corporate Author : Tufts University School of Medicine Boston United States


Personal Author(s) : Yee,Amy S ; Yee,Audrey S


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1017782.pdf


Report Date : 01 Jun 2013


Pagination or Media Count : 11


Abstract : Epileptogenesis is a gradual process by which normal brain transforms into one that sustains seizures. It is instigated by an inciting event (e.g. prolonged seizure called status epilepticus (SE), head injury, infection or stroke). This is followed by a variable (months to years in humans) latent period followed by the emergence of spontaneous seizures, with potential for later mood and learning disabilities. While the latent period is a time during which behavioral seizures are not observed, it is a period of tissue and cellular remodeling that sets up the development of chronic seizure activity, or epilepsy. In this grant, we have drawn expertise from other fields to discover new mechanistic insights into epileptogenesis. In the past year, we have expanded our understanding of molecular mechanisms and uncovered new possible insights for therapeutics with a drug combination that we had been developing for breast cancer treatment. Surprisingly, the combination attenuates seizures in two different models of temporal lobe epilepsy.


Descriptors :   epilepsy , seizures , brain , therapeutics , clinical trials , stokes(cerebral) , head(anatomy) , wounds and injuries , learning disabilities


Distribution Statement : APPROVED FOR PUBLIC RELEASE