Accession Number : AD1017782

Title :   Epilepsy and the Wnt Signaling Pathway

Descriptive Note : Technical Report,01 Jun 2012,03 May 2013

Corporate Author : Tufts University School of Medicine Boston United States

Personal Author(s) : Yee,Amy S ; Yee,Audrey S

Full Text :

Report Date : 01 Jun 2013

Pagination or Media Count : 11

Abstract : Epileptogenesis is a gradual process by which normal brain transforms into one that sustains seizures. It is instigated by an inciting event (e.g. prolonged seizure called status epilepticus (SE), head injury, infection or stroke). This is followed by a variable (months to years in humans) latent period followed by the emergence of spontaneous seizures, with potential for later mood and learning disabilities. While the latent period is a time during which behavioral seizures are not observed, it is a period of tissue and cellular remodeling that sets up the development of chronic seizure activity, or epilepsy. In this grant, we have drawn expertise from other fields to discover new mechanistic insights into epileptogenesis. In the past year, we have expanded our understanding of molecular mechanisms and uncovered new possible insights for therapeutics with a drug combination that we had been developing for breast cancer treatment. Surprisingly, the combination attenuates seizures in two different models of temporal lobe epilepsy.

Descriptors :   epilepsy , seizures , brain , therapeutics , clinical trials , stokes(cerebral) , head(anatomy) , wounds and injuries , learning disabilities

Distribution Statement : APPROVED FOR PUBLIC RELEASE