Accession Number : AD1017186

Title :   New Methods of Low-Field Magnetic Resonance Imaging for Application to Traumatic Brain Injury

Descriptive Note : Technical Report,10 Jan 2011,09 Jan 2016

Corporate Author : Harvard University Cambridge United States

Personal Author(s) : Rosen,Matthew S

Full Text :

Report Date : 01 Apr 2016

Pagination or Media Count : 87

Abstract : We have developed robust low-magnetic-field implementations of MRI (LFI) focused on brain imaging with two complimentary test scanner systems: electromagnet and permanent magnet based. We have also developed injury-sensitive MRI based on the detection of free radicals associated with injury using the Overhauser effect and subsequently imaging that modified nuclear polarization using low-field MRI (OMRI). We have optimized imaging sequences, image reconstruction, and parallel imaging based acceleration in this unique regime. Results include demonstration high-speed brain imaging in the electromagnet LFI at 6.5 mT, preliminary3D imaging in a 100 lb scanner based on a rotating permanent magnet array, and improved free-radical OMRI both in vitro and in vivo. Application of the suite of techniques and technologies from our work could advise future development of a deployable device with a high diagnostic impact, transforming diagnosis and monitoring of secondary injury prevalent in TBI.

Descriptors :   magnetic resonance imaging , BRAIN INJURIES , PERMANENT MAGNETS

Distribution Statement : APPROVED FOR PUBLIC RELEASE