Accession Number : AD1016805


Title :   Underbody Blast Models of TBI Caused by Hyper-Acceleration and Secondary Head Impact


Descriptive Note : Technical Report,06 Jan 2015,05 Jan 2016


Corporate Author : University of Maryland Baltimore United States


Personal Author(s) : Fiskum,Gary ; Fourney,William


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1016805.pdf


Report Date : 01 Feb 2016


Pagination or Media Count : 175


Abstract : There is a high incidence of TBI among warfighter occupants of vehicles targeted by underbody blasts but little is known about the unique forces involved or the pathophysiology. We hypothesize: Acceleration experienced during survivable underbody blasts produces dose-dependent, TBI. Underbody blast-induced acceleration combined with secondary head impact is also military relevant and can be modeled. Neurologic outcome following underbody blast-induced TBI can be improved by force-modifying vehicle hull designs. We will expand our underbody blast animal model of TBI to establish full dose-response relationships and to model the combination of acceleration plus head impact. This research will promote development of engineering- and biomedical-based neuroprotective interventions translatable to warfighter TBI.


Descriptors :   brain injuries , pathophysiology , BLAST INJURIES , inflammation , Concussion , projectiles , helmets , Kinematics , ANIMAL EXPERIMENTATION , Magnetic resonance imaging , Spectroscopy , Apoptosis


Distribution Statement : APPROVED FOR PUBLIC RELEASE