Accession Number : AD1015403


Title :   Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature


Descriptive Note : Journal Article


Corporate Author : USAMRIID Frederick United States


Personal Author(s) : Peck, Michael W ; Smith,Theresa J ; Hill,K K ; Anniballi,F ; Arnon,S S ; Austin,J W ; Bano,L ; Bradshaw,M ; Cuervo,M P ; Cheng,L W ; Derman,Y ; Dorner,B G ; Dover,N ; Fisher,A ; Kalb,S R ; Korkeala,H ; Lindstrom,M ; Lista,F ; Luquez,C ; Mazuet,C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1015403.pdf


Report Date : 26 Aug 2016


Pagination or Media Count : 32


Abstract : Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which presents challenges when organizing the nomenclature surrounding these neurotoxins. Worldwide, researchers are faced with the possibility that toxins having identical sequences may be given different designations, or novel toxins having unique sequences may be given the same designations on publication. In order to minimize these problems, an ad hoc committee consisting of over 20 researchers in the field of botulinum neurotoxin research was convened to discuss clarification of the issues involved in botulinum neurotoxin nomenclature. This publication presents a historical overview of the issues and provides guidelines for botulinum neurotoxin subtype nomenclature in the future.


Descriptors :   bacterial toxins , medical research , history , proteins , microbiology , toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE