Accession Number : AD1015256

Title :   Expanding the Role of Striatal Cholinergic Interneurons and the Midbrain Dopamine System in Appetitive Instrumental Conditioning

Descriptive Note : Journal Article - Open Access

Corporate Author : University of California, Berkeley Berkeley United States

Personal Author(s) : Crossley,Matthew J ; Horvitz,Jon C ; Balsam,Peter D ; Ashby,F G

Full Text :

Report Date : 01 Jan 2016

Pagination or Media Count : 15

Abstract : The basal ganglia are a collection of subcortical nuclei thought to underlie a wide variety of vertebrate behavior. Although a great deal is known about the functional and physiological properties of the basal ganglia, relatively few models have been formally developed that have been tested against both behavioral and physiological data. Our previous work (Ashby FG, Crossley MJ. J Cogn Neurosci 23: 1549-1566, 2011) showed that a model grounded in the neurobiology of the basal ganglia could account for basic single-neuron recording data, as well as behavioral phenomena such as fast reacquisition that constrain models of conditioning. In this article we show that this same model accounts for a variety of appetitive instrumental conditioning phenomena, including the partial reinforcement extinction (PRE) effect, rapid and slowed reacquisition following extinction, and renewal of previously extinguished instrumental responses by environmental context cues.

Descriptors :   brain , human behavior , neurosciences , psychology , cognitive neuroscience , neurons , models , acquisition , simulations , mathematical models , computing system architectures , computational science , artificial neural networks

Subject Categories : Psychology

Distribution Statement : APPROVED FOR PUBLIC RELEASE