Accession Number : AD1015189


Title :   Development of in Vivo Biomarkers for Progressive Tau Pathology after Traumatic Brain Injury


Descriptive Note : Technical Report,15 Jan 2015,14 Jan 2016


Corporate Author : Washington University St Louis United States


Personal Author(s) : Brody,David L ; Diamond,Marc I


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1015189.pdf


Report Date : 01 Feb 2016


Pagination or Media Count : 22


Abstract : Hypothesis: Aggregated forms of hyperphosphorylated tau protein formed acutely in the setting of traumatic brain injury can seed further aggregation of intracellular tau in nearby cells, leading to delayed propagation of tau pathology and neurodegeneration. Objective: To develop standardized, high-throughput blood and cerebrospinal fluid assays for aggregated forms of tau responsible for propagation of tau pathology after traumatic brain injury. Progress to date: To date, none of the attempts to model progressive tau pathology after repetitive concussive TBI in mice has been optimal. Ongoing efforts include development rotational acceleration concussive injury which can be repeated 20 times in the same mice, and subconcussive injuries. Continued progress towards increasing the sensitivity of cell-based assays for tau aggregation activity has been made, as well as antibody-based tau detection methods for blood samples.


Descriptors :   brain injuries , Brain damage , biological markers , neurodegenerative diseases , dementia , Concussion , military personnel , Propagation , cells(biology) , Assaying , chronic encephalopathy


Distribution Statement : APPROVED FOR PUBLIC RELEASE