Accession Number : AD1014810


Title :   Pathology Report for One-Generation Study of the Effects of 3-nitro-1,2,4-triazol-5-one (NTO) to the Northern Leopard Frog (lithobates pipiens) Under Static Renewal Test Conditions


Descriptive Note : Technical Report,01 Oct 2015,29 Feb 2016


Corporate Author : Army Public Health Center (Provisional) Aberdeen Proving Ground United States


Personal Author(s) : Carroll,Erica E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1014810.pdf


Report Date : 28 Dec 2015


Pagination or Media Count : 23


Abstract : Larval (tadpole) northern leopard frogs were exposed to 3-nitro-1,2,4-triazol-5-one (NTO) or to water control until they developed into froglets (up to 90 days) at Gosner Stage 46 (Gosner, 1960). Animals were humanely euthanized and kidney and liver tissues examined microscopically to detect indications of toxicity. No evidence of toxicity or developmental delay was observed, suggesting NTO may not affect anuran renal or hepatic development. Tissues did have inflammatory changes normally associated with infection by mycobacteria, fungi or foreign materials.


Descriptors :   Toxicity , insensitive explosives , frogs , Histopathology , Kidneys , Liver , ANIMAL EXPERIMENTATION


Distribution Statement : APPROVED FOR PUBLIC RELEASE