Accession Number : AD1014805


Title :   Pathology Report for Intraperitoneal Sodium Dichromate Exposure in Rats


Descriptive Note : Technical Report,01 Mar 2015,31 Dec 2015


Corporate Author : Army Public Health Center (Provisional) Aberdeen Proving Ground United States


Personal Author(s) : Carroll,Erica E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1014805.pdf


Report Date : 12 Aug 2015


Pagination or Media Count : 27


Abstract : This project was a collaboration between USACEHR and APHC (Div Tox Path) to process and microscopically evaluate kidney and liver tissues from rats intraperitoneally injected with sodium dichromate dihydrate for a project to identify molecular markers in blood or urine that predict or indicate liver and/or kidney injury resulting from exposure to specific metal intoxication. The investigator aims to validate hypothesized adverse outcome pathways in rats exposed to toxic metals to identify less invasive, rapid biomarkers that could be used in early disease progression. Sodium dichromate dihydrate caused persistent inflammation on the peritoneal surface of liver and kidney tissues after a single injection.


Descriptors :   toxicology , Metals , LIVER , KIDNEYS , RATS , Chromium


Distribution Statement : APPROVED FOR PUBLIC RELEASE