Accession Number : AD1014445

Title :   Identification of Associations Between Genetic Factors and Asthma that are Modified by Obesity

Descriptive Note : Technical Report,01 Feb 2013,01 Oct 2015

Corporate Author : Yale University New Haven

Personal Author(s) : DeWan,Andrew T

Full Text :

Report Date : 01 Jun 2016

Pagination or Media Count : 23

Abstract : We performed a genome-wide gene by environment (asthma) interaction analysis for the outcome of body mass index (BMI) in the Multi-Ethnic Study of Atherosclerosis (MESA) (N=2474 Caucasians, 257 asthmatics) and replicated findings in the Framingham Heart Study (FHS) offspring cohort (N=1408 Caucasians, 382 asthmatics). The replicable tagging single nucleotide polymorphism (SNP) rs2107212 was further examined in stratified analyses. Seven SNPs clustered in 17q21.2 were identified to be associated with higher BMI among asthmatics (interaction p 5 10-7 in MESA and p 0.05 in FHS). Nominally associated copy number variations interacting with BMI were associated with asthma among African American women in the Womens Health Initiative study.

Descriptors :   ethnic groups , cardiovascular diseases , human population , liver diseases , public health , age distribution , body weight , chromosomes , genetics , genomics , demography

Distribution Statement : APPROVED FOR PUBLIC RELEASE