Accession Number : AD1014069


Title :   The Role of Peripheral Nerve Function in Age-Related Bone Loss and Changes in Bone Adaptation


Descriptive Note : Technical Report,30 Sep 2012,29 Sep 2015


Corporate Author : Regents of the University of California Davis United States


Personal Author(s) : Christiansen,Blaine A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1014069.pdf


Report Date : 01 Dec 2015


Pagination or Media Count : 142


Abstract : Current osteoporosis therapies are able to treat the symptoms of osteoporosis, however little progress has been made toward understanding and addressing the underlying mechanisms contributing to age-related bone loss, or the ability to adapt to mechanical loading (exercise). Degeneration in peripheral nerve function with age may be one of these mechanisms, as neuropeptides affect the function of osteoblasts and osteoclasts in vitro, and nerve deactivation causes bone loss in vivo. This research investigates mechanisms by which peripheral sensory nerves influence bone maintenance and mechanotransduction using capsaicin-injected mice as a model of decreased peripheral sensory nerve function. We hypothesize that decreased sensory nerve function will result in increased functional adaptation of bone. In Aim 1 we investigated the relationship betweenperipheral sensory nerve function and bone structure.


Descriptors :   Peripheral nervous system , OSTEOPOROSIS , BONES , adaptation (physiology) , structural properties , aging (physiology) , Degeneration (physiology) , exercise (physiology) , nerve cells


Distribution Statement : APPROVED FOR PUBLIC RELEASE