Accession Number : AD1013996


Title :   The Effect of Traumatic Stress on Multiple Aminergic Systems in the Basolateral Amygdala and Hypothalamus: Specific Impairment of Serotonin 5-HT2a Receptor Signaling and its Pathophysiological Role in an Animal Model of Post Traumatic Stress Disorder


Descriptive Note : Technical Report


Corporate Author : Uniformed Services University Of The Health Sciences Bethesda United States


Personal Author(s) : Jiang,Xiaolong


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1013996.pdf


Report Date : 27 Feb 2007


Pagination or Media Count : 200


Abstract : The amygdala and hypothalamus are central brain regions participating in stress response. This response also requires participation of multiple aminergic systems, which extensively interconnect with the amygdala and hypothalamus. Thus, dysregulation of aminergic systems, particularly the serotonergic and noradrenergic systems, is closely linked with multiple anxiety and stress disorders. The present study, utilizing a learned helplessness stress model, determined if alterations of aminergic systems in the amygdala and hypothalamus were involved in stress-induced behavioral and physiological abnormalities associated with anxiety and stress disorders.


Descriptors :   hypothalamus , brain , TRAUMATIC STRESS DISORDER , ANXIETY DISORDERS , ELECTROPHYSIOLOGICAL PHENOMENA


Subject Categories : Medicine and Medical Research
      Psychology


Distribution Statement : APPROVED FOR PUBLIC RELEASE