Accession Number : AD1013498


Title :   Evaluation of NF-B Signaling in T Cells


Descriptive Note : Technical Report


Corporate Author : Uniformed Services University of the Health Sciences Bethesda United States


Personal Author(s) : Kingeter,Lara M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1013498.pdf


Report Date : 01 Jan 2009


Pagination or Media Count : 71


Abstract : The studies presented in this thesis describe experiments designed to increase our understanding of how T cells transduce activating signals to the transcription factor NF-B, and to better understand the kinetic nature of NF-B signaling. The overarching goals of this thesis are 1) to evaluate T cell receptor mediated activation of the transcription factor NF-B in the absence of key signaling proteins, and 2) to define the mechanisms of signal transduction to NF-B by identifying the point at which signaling becomes digital in nature.


Descriptors :   cells(biology) , Transcription(Genetics) , Receptor sites(Physiology) , kinetics , cellular structures , lymphocytes , transcription factors , gene expression , adaptive immunity


Distribution Statement : APPROVED FOR PUBLIC RELEASE