Accession Number : AD1013498

Title :   Evaluation of NF-B Signaling in T Cells

Descriptive Note : Technical Report

Corporate Author : Uniformed Services University of the Health Sciences Bethesda United States

Personal Author(s) : Kingeter,Lara M

Full Text :

Report Date : 01 Jan 2009

Pagination or Media Count : 71

Abstract : The studies presented in this thesis describe experiments designed to increase our understanding of how T cells transduce activating signals to the transcription factor NF-B, and to better understand the kinetic nature of NF-B signaling. The overarching goals of this thesis are 1) to evaluate T cell receptor mediated activation of the transcription factor NF-B in the absence of key signaling proteins, and 2) to define the mechanisms of signal transduction to NF-B by identifying the point at which signaling becomes digital in nature.

Descriptors :   cells(biology) , Transcription(Genetics) , Receptor sites(Physiology) , kinetics , cellular structures , lymphocytes , transcription factors , gene expression , adaptive immunity

Distribution Statement : APPROVED FOR PUBLIC RELEASE