Accession Number : AD1013357


Title :   Activation of mTor Signaling by Gene Transduction to Induce Axon Regeneration in the Central Nervous System Following Neural Injury (Addendum)


Descriptive Note : Technical Report,21 Feb 2015,20 Feb 2016


Corporate Author : Columbia University Medical Center New York United States


Personal Author(s) : Burke,Robert E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1013357.pdf


Report Date : 01 Mar 2016


Pagination or Media Count : 13


Abstract : A long-standing belief about injuries and diseases of the brain and spinal cord has been that once axons are destroyed, they will not re-grow. This belief is now being challenged. As the brain matures, the genetic programs that control axon growth during development are silenced. Recent evidence shows that re-activation of these programs in the adult successfully induces axon growth. We have shown that re-activation of Akt/mTORC1 signaling, by use of AAV vector transfer, induces regrowth of dopaminergic axons at 3 to 6 weeks after destruction by a neurotoxin. However, this approach cannot be used inhumans because Akt/mTORC1 signaling is oncogenic. The goal of this proposal is to refine this approach to achieve restorative effects in the absence of adverse effects.


Descriptors :   BRAIN INJURIES , central nervous system , neural cells , GROWTH (PHYSIOLOGY) , regeneration (PHYSIOLOGY) , NEUROCHEMISTRY , NERVE DEGENERATION , proteins , gene expression


Distribution Statement : APPROVED FOR PUBLIC RELEASE