Accession Number : AD1013338


Title :   The Parkinsons Registry Investigation of Diagnosis and Etiology (PRIDE) Study


Descriptive Note : Technical Report,01 Apr 2015,31 Mar 2016


Corporate Author : Northern California Institute for Research and Education San Francisco United States


Personal Author(s) : Tanner,Caroline M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1013338.pdf


Report Date : 01 Apr 2016


Pagination or Media Count : 10


Abstract : Exposure to pesticides, solvents or traumatic brain injury increase PD risk. This study takes advantage of the population-based PD registry in Santa Clara County, California and extensive state toxicants databases to investigate the causes of PD and PD-related morbidity and mortality. Study Design: Phase 1: The residence history of more than 3,000 PD cases from the population-based PD registry will be linked to geographically-specific exposure information to determine the relationship between toxicant exposure and PD incidence, morbidity and mortality using Cox proportional hazards regression with time-varying measures of chronic exposure, adjusting for confounding. Phase 2: Conduct a case-control study in a stratified random sample of cases and matched controls, collecting information on occupation, traumatic brain injury, and lifestyle risk factor information and conducting exams. Relevance: This work can help identify the causes and, ultimately, ways to prevent PD.


Descriptors :   CENTRAL NERVOUS SYSTEM DISEASES , databases , public health , morbidity , environmental health


Distribution Statement : APPROVED FOR PUBLIC RELEASE