Accession Number : AD1013333


Title :   Development of an Autologous Macrophage-based Adoptive Gene Transfer Strategy to Treat Posttraumatic Osteoarthritis (PTOA) and Osteoarithritis (OA)


Descriptive Note : Technical Report,01 Sep 2013,28 Feb 2016


Corporate Author : Loma Linda University Loma Linda United States


Personal Author(s) : Sheng,Matilda H C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1013333.pdf


Report Date : 01 May 2016


Pagination or Media Count : 28


Abstract : OA is the most common degenerative joint disease, and 12 of all OA are resulted from an acute trauma to the joint and are referred to as PTOA. There is no cure for PTOA or OA. This Discovery Award project seeks to obtain proof-of-concept type of evidence for the feasibility of and efficacy for an innovative autologous macrophage- based anti-catabolic and pro-chondrogenic combination adoptive gene therapy for treatment of PTOA. The rationale for the use of macrophages as the cell vehicle for targeted delivery and confined expression of the transgene(s) is based on definitive evidence that a) PTOA development is associated with both acute and chronic inflammation of the synovium; and b) synovial inflammation triggers massive infiltration of activated macrophages. The idea of the combination macrophage-based adoptive gene therapy with both an anti-catabolic gene (IL-1ra or IL-1 shRNA) and a pro-chondrogenic gene (TGF3) is based on the assumption that comprehensive treatment of a disease with complex pathophysiology, such as PTOA, will require concerted treatments at multiple phases of the diseases.


Descriptors :   arthritis , joints(anatomy) , GENE THERAPY , macrophages , inflammation , military personnel , wounds and injuries , therapeutics


Distribution Statement : APPROVED FOR PUBLIC RELEASE