Accession Number : AD1013055


Title :   Host Cell Virus Entry Mediated by Australian Bat Lyssavirus Envelope G glycoprotein


Descriptive Note : Technical Report


Corporate Author : Uniformed Services University Of The Health Sciences Bethesda United States


Personal Author(s) : Weir,Dawn L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1013055.pdf


Report Date : 24 Oct 2013


Pagination or Media Count : 185


Abstract : Australian bat lyssavirus (ABLV) is a recently emerged rhabdovirus of the genuslyssavirus considered endemic in Australian bat populations that causes a neurological disease in people indistinguishable from clinical rabies. There are two distinct variants of ABLV, one that circulates in frugivorous bats (genus Pteropus) and the other in insectivorous microbats (genus Saccolaimus). Three fatal human cases of ABLV infection have been reported, the most recent in 2013, and each manifested as acuteencephalitis but with variable incubation periods. Importantly, two equine cases also arose recently in 2013; the first occurrence of ABLV in a species other than bats or humans. ABLV infects host cells through receptor-mediated endocytosis and subsequent pH-dependent fusion facilitated by its single fusogenic envelope glycoprotein (G), but the specific host factors and pathways involved in ABLV entry have not been determined.


Descriptors :   viruses , animal diseases , GLYCOPROTEINS , neurons , cellular structures , bats


Distribution Statement : APPROVED FOR PUBLIC RELEASE