Accession Number : AD1013003


Title :   Identification of the GnRH-(1-5) Receptor and Signaling Pathway


Descriptive Note : Technical Report


Corporate Author : Uniformed Services University Of The Health Sciences Bethesda United States


Personal Author(s) : Larco,Darwin O


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1013003.pdf


Report Date : 22 Mar 2013


Pagination or Media Count : 133


Abstract : The decapeptide gonadotropin-releasing hormone (GnRH) is a central regulator of pubertal onset and reproductive function. In mammals, GnRH is released into the medianeminence of the hypothalamus to stimulate the pituitary release of the gonadotropins. Inturn, these hormones regulate the gonadal production of steroid hormones, which act as feedback modulators of the GnRH neuroendocrine system. Developmental defects in this regulation can lead to hypogonadotropic hypogonadism where the onset of puberty and fertility are impaired. Such is the case in patients suffering from Kallmann Syndrome (KS) where GnRH neurons emanating from the olfactory placode during development do not reach their destination within the central nervous system. Despite ongoing research in this field, a complete molecular understanding in the development of KS remains elusive.


Descriptors :   medical research , peptides , receptor sites(physiology) , hypothalamus , pituitary hormones , identification , gonadotropins , theses


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE