Accession Number : AD1012913


Title :   Differential Expression of Phosphorylated Mitogen-Activated Protein Kinase (pMAPK) in the Lateral Amygdala of Mice Selectively Bred for High and Low Fear


Descriptive Note : Technical Report


Corporate Author : Uniformed Services University Of The Health Sciences Bethesda United States


Personal Author(s) : Coyner,Jennifer L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1012913.pdf


Report Date : 02 Jul 2013


Pagination or Media Count : 129


Abstract : Post traumatic stress disorder (PTSD) is a serious medical condition affecting both military and civilian populations. While its etiology remains poorly understood PTSD is characterized by high and prolonged levels of fear response. The neuronal processing of fear occurs in the amygdala, a complex structure located in the temporal lobe of the brain. A known requirement for the long-term storage or consolidation of fear memory is the phosphorylation of mitogen activated protein kinase (p44/42 (ERKl/2)pMAPK) in the lateral amygdala (LA), a sub-nucleus of the amygdala. Increased expression of pMAPK in the LA is a reliable marker of the neuroplasticity underlying fear learning. One important biological unknown however, is whether individuals expressing high or low conditioned fear memory consolidate the memory differently, and if that difference underlies differences in fear response. A strategy for investigating this question is to examine the regional expression of pMAPK in the amygdala in animals that exhibit high and low fear.


Descriptors :   BRAIN , POST TRAUMATIC STRESS DISORDER , Phosphorylation , MEMORY(PSYCHOLOGY) , KINASES , Fear , Mice , INHIBITORS


Distribution Statement : APPROVED FOR PUBLIC RELEASE