Accession Number : AD1012633


Title :   Cross-Species Virus-Host Protein-Protein Interactions Inhibiting Innate Immunity


Descriptive Note : Technical Report,03 Dec 2012,17 Mar 2016


Corporate Author : Hauptman-Woodward Medical Research Institute Buffalo United States


Personal Author(s) : Umland,Timothy C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1012633.pdf


Report Date : 01 Jul 2016


Pagination or Media Count : 30


Abstract : The single-stranded negative sense RNA (ssRNA(-)) virus families Arenaviridae, Orthomyxoviridae, and Paramyxoviridae include some of the most deadly emerging zoonotic pathogens. These viruses are known to impair antiviral interferon activation responses in humans through virus-host protein-protein interactions (PPIs) that disrupt intracellular signaling pathways. However, little is known about the role of homologous PPIs in animal (donor) hosts and the extent of adaption necessary to form similar complexes in new (recipient) hosts. The present work seeks to characterize the importance of PPIs in species jumping events.


Descriptors :   Pathogenic microorganisms , ZOONOTIC DISEASES , proteins , rna virus infections , rna viruses , sequence analysis


Distribution Statement : APPROVED FOR PUBLIC RELEASE