Accession Number : AD1012572


Title :   Treatment-Induced Autophagy Associated with Tumor Dormancy and Relapse


Descriptive Note : Technical Report,01 Jul 2015,30 Jun 2016


Corporate Author : Virginia Commonwealth University Richmond United States


Personal Author(s) : Manjili,Masoud


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1012572.pdf


Report Date : 01 Jul 2016


Pagination or Media Count : 35


Abstract : Studies relating to the role autophagy in tumor dormancy revealed that transient inhibition of autophagy during ADR treatment resulted in prolonging tumor dormancy. However, complete knockdown of autophagy gene expedited tumor relapse. We also identified two distinct types of ADRinduced tumor dormancy including Ki67 /low indolent and Ki67 quiescent tumor dormancy. Whereas that former was sensitive to immunoediting, escape and relapse, the latter was found to be resistant to tumor immunoediting and escape. Adoptive immunotherapy (AIT) was also found to support regression of ADRinduced dormant tumor cells.


Descriptors :   neoplasms , immunotherapy , chemotherapy , cell physiological processes , apoptosis , bone marrow , immunomodulation , drug therapy , breast cancer , lymphocytes , infectious diseases


Distribution Statement : APPROVED FOR PUBLIC RELEASE