Accession Number : AD1012160


Title :   Targeting Sulfotransferase (SULT) 2B1b as a Regulator of Cholesterol Metabolism in Prostate Cancer


Descriptive Note : Technical Report,30 Sep 2014,29 Sep 2015


Corporate Author : Purdue University West Lafayette United States


Personal Author(s) : Ratliff,Timothy


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1012160.pdf


Report Date : 01 Oct 2015


Pagination or Media Count : 15


Abstract : Abundant epidemiological and experimental evidence establishes alterations in cholesterol metabolism as a key driver of prostate cancer (PCa) aggressiveness. Our preliminary data shows cholesterol sulfotransferase (SULT) 2B1b, a global regulator of cholesterol metabolism, is overexpressed in human prostate neoplasia and PCa cell lines and that genetic knock down suppresses LNCaP growth and diminishes androgen receptor (AR) activity. It is hypothesized that SULT2B1b modulates PCa growth and phenotype via alterations in cholesterol metabolism. If validated, the studies will form the foundation for novel therapeutic intervention. The primary objective of these studies is to define the role of SULT2B1b in PCa on growth,sensitivity to androgens, and apoptosis based on the central hypothesis that SULT2B1b regulates malignant phenotypes via regulation of cholesterol metabolism. The pivotal role of SULT2B1b inregulating cholesterol homeostasis in PCa is a novel observation that when better defined by the studies outlined in this application, will provide the foundation for new approaches for controlling cholesterol dysregulation in PCa.


Descriptors :   cholesterol , metabolism , prostate cancer , androgens , apoptosis


Distribution Statement : APPROVED FOR PUBLIC RELEASE