Accession Number : AD1011820

Title :   Effects of Nicotine Administration and Stress on Sensory-Gating Depend on Rat Strain and Sex

Descriptive Note : Technical Report

Corporate Author : Uniformed Services University Of The Health Sciences Bethesda United States

Personal Author(s) : Faraday,Martha M

Full Text :

Report Date : 01 Jan 1998

Pagination or Media Count : 158

Abstract : The present experiments investigated effects of nicotine administration, nicotine cessation, and stress (environmental and physical) on the acoustic startle reflex (ASR)and pre-pulse inhibition (ppn of the ASR (measures of sensory-gating) in males and females of two rat strains. Experiment 1 examined effects of nicotine on 192 Long-Evans rats (a non-albino strain) in individual or crowded housing. For males, nicotine increased startle and PPI in the crowded condition but decreased these responses in the individually-housed condition. For females, nicotine reduced ASR and PPI regardless of housing condition. Experiment 2 examined effects of nicotine (0, 6, or 12 mg/kglday) and immobilization (IM) stress on ASR and PPI of male and female Long-Evans and Sprague-Dawley (albino) rats (N = 240). Nicotine decreased ASR and PPI responses of Long-Evans subjects. Nicotine enhanced Sprague-Dawley subjects' responses. Stress increased responses of Sprague-Dawley males and Long-Evans females but decreased responses of Sprague-Dawley females and Long-Evans males.


Distribution Statement : APPROVED FOR PUBLIC RELEASE