Accession Number : AD1011714


Title :   Microenvironments and Signaling Pathways Regulating Early Dissemination, Dormancy, and Metastasis


Descriptive Note : Technical Report,01 Sep 2014,31 Aug 2015


Corporate Author : Albert Einstein College of Medicine Bronx


Personal Author(s) : Condeelis,John ; Aguirre-Ghiso,Julio


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1011714.pdf


Report Date : 01 Sep 2015


Pagination or Media Count : 50


Abstract : We have evidence for the existence of a structure called tumor microenvironment of metastasis or TMEM, which is composed by a proangiogenic macrophage a, a Mena overexpressing tumor cell and an endothelial cell where the three cell complex is in direct contact with a blood vessel wall. We detected primary tumor TMEM (P-TMEM) in pre-malignant lesions. The P-TMEM is required to support early dissemination of pre- malignant neoplastic cells (early DTCs). We further hypothesize that after extravasation at secondary site TMEM (STMEM),in order to exit dormancy a stable S-TMEM structure needs to be maintained and that early DTCs cannot sustain its assembly possibly because they lack a persistent proangiogenic M recruiting program. Our rationale is that by understanding early dissemination and dormancy of DTCs we will find ways to eradicate dormant DTCs and prevent metastasis.


Descriptors :   dormancy , neoplasms , metastasis , cancer research , biological markers , breast cancer


Distribution Statement : APPROVED FOR PUBLIC RELEASE