Accession Number : AD1011529


Title :   Biochemical Effects of Cadmium Exposure and the Potential Pharmacologic Significance of Cadmium Mediated Hydrolase Inhibition


Descriptive Note : Technical Report


Corporate Author : Uniformed Services University of the Health Sciences Bethesda United States


Personal Author(s) : Nix,Darrell J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1011529.pdf


Report Date : 18 Apr 1997


Pagination or Media Count : 125


Abstract : The objective of this research was to explore the possible existence of an adverse effect resulting from exposure to cadmium (Cd) within levels allowed or recommended to be without adverse effect. The central hypothesis that we tested was that the exposure of Sprague-Dawley rat to Cd (2 mg CdC12/kg, administered i.p.) would reduce non-specific serum and tissue hydrolase activity enough to alter the metabolism of an ester compound like methylphenidate. The knowledge that metals affect the function of enzymes was the rationale behind an initial investigation attempting to identify an enzyme that could be used as a biomarker of Cd exposure. It was discovered that Cd was capable of reducing the activity of rat serum hydrolase. The hydrolases are ubiquitous enzymes that are known to be active participants in the hydrolysis of many foreign toxic and therapeutic compounds. However, the physiological role of the esterases is unclear.


Descriptors :   TOXICITY , TOXICOLOGY , CADMIUM , PHARMACOLOGY , HYDROLASES , rats


Distribution Statement : APPROVED FOR PUBLIC RELEASE