Accession Number : AD1011486


Title :   Magnesium Sulfate and Betamethasone Reduce NUR77 Expression in a Preterm Labor Mouse Model


Descriptive Note : Technical Report,20 Dec 2013,29 Jun 2016


Corporate Author : Madigan Army Medical Center Tacoma United States


Personal Author(s) : Thagard,Andrew S ; Ieronimakis,Nicholas M ; Lutgendorf,Monica A ; Ippolito,Danielle L ; Napolitano,Peter G


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1011486.pdf


Report Date : 29 Jun 2016


Pagination or Media Count : 11


Abstract : Women in preterm labor are commonly treated with magnesium sulfate (MgSO4) and betamethasone (BMTZ) to reduce complications of prematurity including neurologic injury. MgSO4, however, prevents cerebral palsy in only 1 in 40 women who receive it. Understanding the cellular responses to MgSO4/BMTZ could allow for more effective treatments. Nur77 is a nuclear receptor implicated in apoptosis and immune responses- processes that occur in neuroinflammation. Our objective was to investigate if Nur77 is increased in the setting of inflammation-induced preterm labor and determine the impact of MgSO4 and BMTZ treatments.


Descriptors :   Magnesium sulfates , mice , models , Pregnancy , apoptosis , response (biology) , gene expression , histology , inflammation , Lipopolysaccharides , embryos , brains


Distribution Statement : APPROVED FOR PUBLIC RELEASE