Accession Number : AD1011463

Title :   Characterization of the Virus and Monoclonal Antibody Binding Sites of the Mouse Hepatitis Virus Receptor

Descriptive Note : Technical Report

Corporate Author : Uniformed Services University Of The Health Sciences Bethesda United States

Personal Author(s) : Shick,Paul C

Full Text :

Report Date : 16 Oct 1995

Pagination or Media Count : 106

Abstract : The attachment of Mouse Hepatitis Virus (MHV), a coronavirus, to its cellular receptor on the host cell membrane is the first step leading to viral infection. The best characterized receptor for MHV is a 120 kDa glycoprotein encoded by the biliary glycoprotein (Bgp) la gene. Other murine Bgp glycoproteins also serve as receptors for MHV but with less efficiency. Bgps belong to the carcinoembryonic antigen family which, in turn, belongs to the immunoglobulin superfamily. Chimeric glycoproteinsand recombinant mutated receptor proteins were generated to identify the sites on the receptor that binds to the Mouse Hepatitis Virus strain AS9 (MHV-AS9).

Descriptors :   Hepatitis viruses , Monoclonal Antibodies , mice , Receptor sites (Physiology) , Glycoproteins , genes , amino acids , deoxyribonucleic acids , nucleotides , mutations , cells (biology)

Distribution Statement : APPROVED FOR PUBLIC RELEASE