Accession Number : AD1011455


Title :   Targeting Signaling to YAP for the Therapy of NF2


Descriptive Note : Technical Report,30 Sep 2014,29 Sep 2015


Corporate Author : Memorial Sloan Kettering Cancer Center New York United States


Personal Author(s) : Giancotti,Filippo G


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1011455.pdf


Report Date : 01 Oct 2015


Pagination or Media Count : 12


Abstract : The goals of this Application are to utilize our new knowledge of the mechanism by which loss of Merlin induces tumorigenesis to identify small molecule compounds that block YAP/TEAD-dependent transcription by acting at any step of our newly identified pathway, and to test the preclinical efficacy of lead compounds in xenograft models of NF2. During the first year of this grant, we have generated NF2 mutant cell lines expressing two different types of YAP reporters and tested their suitability for high throughput screening.


Descriptors :   genes , neoplasms , mutations , cells (biology)


Distribution Statement : APPROVED FOR PUBLIC RELEASE