Accession Number : AD1011367


Title :   Cleveland Clinic Rehabilitation Research Program


Descriptive Note : Technical Report,15 Sep 2011,14 Sep 2015


Corporate Author : Cleveland Clinic Cleveland United States


Personal Author(s) : Lin,Vernon


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1011367.pdf


Report Date : 01 Dec 2015


Pagination or Media Count : 32


Abstract : Study 1: The penicillin-induced seizure animal model has been generated by acute focal intracortical injection of penicillin in the motor cortex of rats. The effects of functional magnetic stimulation (FMS) on penicillin-induced seizure have been investigated using behavioral recording and electroencephalographic (EEG) recording. Study 2: The motor cortex (M1) and the corticospinal tracts (CST) will be directly modulated using brain stimulation to benefit rehabilitative outcomes of upper limb training in incomplete SCI (iSCI). Eight patients and three healthy control subjects have been enrolled. SCI patients receiving brain stimulation show greater benefit in upper limb function than those receiving rehabilitation alone.Study 3: The efficacy of using FMS for respiratory muscle conditioning is evaluated in patients with multiple sclerosis (MS). Four patient with MS have been enrolled. A 6-week FMS conditioning of the expiratory muscles improved voluntary expiratory functions, indicating that FMS may be a potential noninvasive therapeutic technology for training respiratory muscles in patients with MS. Study 4: This pilot study will evaluate the usefulness of FMS as a noninvasive method to stimulate the GI motility in individuals with non-neurological constipation. The PI worked with HRPO to modify the protocol (remove the sham treatment).


Descriptors :   penicillins , seizures , brain , ELECTRIC STIMULATION THERAPY , NERVOUS SYSTEM DISEASES , therapeutics , RESPIRATORY SYSTEM


Distribution Statement : APPROVED FOR PUBLIC RELEASE