Accession Number : AD1011336


Title :   Dissociation of Down Syndrome and Alzheimers Disease Effects With Imaging


Descriptive Note : Journal Article


Corporate Author : ADM Diagnostics Northbrook United States


Personal Author(s) : Matthews,Dawn C ; Lukic,Ana S ; Andrews,Randolph D ; Marendic,Boris ; Brewer,James ; Rissman,Robert A ; Mosconi,Lisa ; Strother,Stephen C ; Wernick,Miles N ; Mobley,William C ; Ness,Seth ; Schmidt,Mark E ; Rafii,Michael S


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1011336.pdf


Report Date : 29 Aug 2016


Pagination or Media Count : 13


Abstract : Introduction: Down Syndrome (DS) adults experience accumulation of Alzheimers disease (AD)like amyloid plaques and tangles and a high incidence of dementia and could provide an enriched population to study AD-targeted treatments. However, to evaluate effects of therapeutic intervention, it is necessary to dissociate the contributions of DS and AD from overall phenotype. Imaging biomarkers offer the potential to characterize and stratify patients who will worsen clinically but have yielded mixed findings in DS subjects. Methods: We evaluated 18F fluorodeoxyglucose positron emission tomography (PET), florbetapir PET, and structural magnetic resonance (sMR) image data from 12 nondemented DS adults using advanced multivariate machine learning methods. Results: Our results showed distinctive patterns of glucose metabolism and brain volume enabling dissociation of DS and AD effects. AD-like pattern expression corresponded to amyloid burden and clinical measures. Discussion: These findings lay groundwork to enable AD clinical trials with characterization and disease-specific tracking of DS adults.


Descriptors :   brain , biological markers , alzheimer disease , dementia , Genetic diseases , neuroimaging , diagnostic imaging , machine learning , metabolism , Glucose , positron emission tomography , magnetic resonance imaging , Clinical trials


Distribution Statement : APPROVED FOR PUBLIC RELEASE