Accession Number : AD1010963


Title :   Novel Protection and Decontamination Strategies


Descriptive Note : Technical Report,05 Apr 2009,04 Apr 2011


Corporate Author : Florida Gulf Coast University Fort Myers United States


Personal Author(s) : Isern,Sharon ; Barreto,Jose ; Michael,Scott F


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1010963.pdf


Report Date : 01 Jun 2016


Pagination or Media Count : 58


Abstract : The basic premise of this work was to conduct basic science investigations into novel technologies to protect against and decontaminate biological agents and toxins that can be applied to both civilian and military use. The work can be divided into investigations into two broad topic areas: development of novel rationally designed virus inactivation strategies and novel environmentally benign disinfection systems. The virus inactivation work during this project led to: (1) The discovery and characterization of multiple distinct peptide inhibitors of dengue virus infectivity, including novel chemically modified peptide inhibitors with improved pharmacological properties. (2) The first description and characterization of the human humoral immune response against dengue virus in the form of human monoclonal antibodies against the virus surface envelope protein. Many of these antibodies show neutralizing activity against dengue virus and can form the basis of prophylactic or therapeutic treatments. The decontamination work during this project led to: (3) Invention and final patent application for a family of new switchable germicides with sub-contractor testing showing excellent efficacy against bacterial pathogens. (4) The discovery that a combination of bromide and ferric ions greatly enhanced photocatalytic destruction of a lipid target, with a bromide mediated mechanism, creating products similar to those observed during gamma ray decontamination.


Descriptors :   Dengue virus , inhibitors , peptides , Monoclonal antibodies , Germicides , Decontamination , Biocides , assaying


Distribution Statement : APPROVED FOR PUBLIC RELEASE