Accession Number : AD1010648

Title :   Regulation of Pituitary Beta Endorphin Release: Role of Serotonin Neurons

Descriptive Note : Technical Report

Corporate Author : Uniformed Services University Of The Health Sciences Bethesda United States

Personal Author(s) : Malcolm,Diana S

Full Text :

Report Date : 15 Dec 1983

Pagination or Media Count : 198

Abstract : Beta-Endorphin-like immunoreactivity (B-END-LI) is present In highest concentration in the anterior (AL) and intermediate lobe (IL) of the pituitary gland from where it is released in response to pain and other stimuli. Several lines of evidence suggest that serotonin neurons influence nociception via mechanisms which involve opiate receptors and the release of endogenous opiate peptides within the central nervous system (CNS) and possibly from the pituitary. The purpose of the presentresearch was to determine whether serotonin neurons are involved in the regulation of pituitary B-END-LI secretion and therefore provide evidence for a functional relationship between serotonergic-stimulated release of pituitary B-END-LI and endogenous mechanisms of analgesia. Since the pituitary is the major source for blood-borne B-END-LI, the effects of serotonergic drugs on plasma levels of B-END-LI was used to study serotonergic control over pituitary 3-endorphin.

Descriptors :   Pituitary gland , serotonin , peptides , central nervous system , Secretion , analgesia , drugs , blood plasma , Endorphins , Tryptophan , brain , drugs , Biosynthesis , neurons , receptor sites (physiology) , sampling , tissues (biology) , assaying , Stimulation (Physiology)

Distribution Statement : APPROVED FOR PUBLIC RELEASE