Accession Number : AD1010634


Title :   Vitamin D and Related Genes, Race and Prostate Cancer Aggressiveness


Descriptive Note : Technical Report,30 Sep 2011,29 Sep 2015


Corporate Author : South Carolina Research Foundation Columbia United States


Personal Author(s) : Steck,Susan E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1010634.pdf


Report Date : 29 Dec 2015


Pagination or Media Count : 34


Abstract : The overall goal of the study is to examine whether altered vitamin D status (as measured by serum metabolites and by functional polymorphisms within genes related to vitamin D transport, metabolism and activity) is associated with increased risk of aggressive prostate cancer, and may explain some of the racial disparity seen in aggressive prostate cancer. All of the project activities as outlined in the Statement of Work Tasks and Milestones are complete. IRB approval was obtained from all local institutions and the DoD HSRRB. The study team participated in regular conference calls to discuss study progress and data collection and analyses throughout the grant period. All assays have been performed and data have been merged and cleaned. Statistical analyses for the main project aims are complete, with additional analyses underway. With the large representation of African Americans in this investigation, the research provides insights into the role of vitamin D in prostate cancer among a chronically underserved population carrying an unequal burden of disease.


Descriptors :   vitamin d , genetic variation , prostate cancer , ethnic groups , minority groups , african Americans , polymorphism


Distribution Statement : APPROVED FOR PUBLIC RELEASE