Accession Number : AD1010535

Title :   Effect of Teriparatide, Vibration and the Combination on Bone Mass and Bone Architecture in Chronic Spinal Cord Injury

Descriptive Note : Technical Report,27 Sep 2010,26 Sep 2015

Corporate Author : Northwestern University Evanston United States

Personal Author(s) : Schnitzer,Thomas J

Full Text :

Report Date : 01 Dec 2015

Pagination or Media Count : 51

Abstract : Severe bone loss commonly occurs in individuals with chronic spinal cord injury who are non-weight-bearing and leads to an increased risk of lower extremity fractures. This 12 month, multi-site, double-blind, randomized, placebo-controlled study evaluates the efficacy and safety of two interventions known to be anabolic to bone, parathyroid hormone and mechanical loading (provided as teriparatide and vibration, respectively) in 60 SCI individuals with low bone mass. 56 out of 60 participants (retention rate of 93 ) completed the initial treatment period (1 year); 24 of 25 participants who elected to enter a 1 year open-label extension of teriparatide therapy have recently completed. No safety issues have arisen during the course of the study. The data from the first year of treatment show no statistically significant difference among the 3 treatment groups in bone density or bone strength at any skeletal site despite bone marker data demonstrating a metabolic response to teriparatide but not to vibration alone. Results from the second year of treatment are not yet available.

Descriptors :   spinal cord , wounds and injuries , density , osteoporosis , vibration , bone and bones , Hormones

Distribution Statement : APPROVED FOR PUBLIC RELEASE