Accession Number : AD1010021


Title :   Toxicology Study No. S.0024589d 15, Human Cell Line Activation Test of the Novel Energetic, 3,4 -Dinitropyrazole (DNP)


Descriptive Note : Technical Report,01 Mar 2016,30 Apr 2016


Corporate Author : Army Public Health Center (Provisional) Aberdeen Proving Ground United States


Personal Author(s) : Reinke,Emily N


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1010021.pdf


Report Date : 01 Apr 2016


Pagination or Media Count : 23


Abstract : The novel energetic 3,4-dinitropyrazole (DNP) is under consideration as a replacement for trinitrotoluene (TNT) in explosive formulations. The toxicological properties of DNP are under evaluation as part of this effort. This study assessed the skin sensitization potential of DNP through the human cell line activation test (h-CLAT), an in vitro approach to assess dendritic cell activation by chemicals, a critical step in the elicitation of a skin allergy. 3,4-DNP was found to be a sensitizer.


Descriptors :   TOXICOLOGY , MILITARY MEDICINE , MILITARY RESEARCH , PUBLIC HEALTH , TOXICOLOGY , EXPLOSIVES , HEALTH , TNT , TEST AND EVALUATION


Distribution Statement : APPROVED FOR PUBLIC RELEASE