Accession Number : AD1009873


Title :   Combat-Related Heterotopic Ossification: Development of Animal Models for Identifying Mechanisms and Testing Therapeutics


Descriptive Note : Technical Report,15 Jun 2014,14 Jun 2015


Corporate Author : The Geneva Foundation Lakewood United States


Personal Author(s) : Forsberg,Jonathan A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1009873.pdf


Report Date : 01 Jul 2015


Pagination or Media Count : 26


Abstract : HO is occurring at significantly higher frequencies in the current war-wounded population than in civilian populations and it is a common and significant problematic clinical entity for war-wounded patients. The available body of evidence suggests that polytraumatic blast injuries induce HO with high frequency as a result of a combination of systemic and local factors. Prevention of HO through the development of prophylactic treatments would reduce military treatment costs and the pain and suffering of Wounded Warriors. A critical hurdlein our investigation of HO etiology, treatment, and prevention is the absence of a reliable and reproducible small animal model that can be used to characterize combatrelated HO development, identify new prophylactic/therapeutic targets, and test new HO countermeasures.


Descriptors :   osteogenesis , combat forces , wound and injuries , amputation , inflammation , blast , overpressure , healing


Distribution Statement : APPROVED FOR PUBLIC RELEASE