Accession Number : AD1009578


Title :   Engineered Joint Lubrication for OA Prevention and Treatment


Descriptive Note : Technical Report,15 Aug 2014,14 Aug 2015


Corporate Author : JOHNS HOPKINS HOSPITAL BALTIMORE MD BALTIMORE United States


Personal Author(s) : Elisseeff,Jennifer


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1009578.pdf


Report Date : 01 Sep 2015


Pagination or Media Count : 22


Abstract : 1. Engineer a 1-step injection technology to modify the cartilage-fluid interface to reduce friction and ultimately joint degradation. We will leverage our new HA-binding peptide technology to functionalize normal and arthritic cartilage surfaces to localize and bind the synovial lubricant and biofunctional molecule HA, a current mainstay in clinical practice today to reduce pain and delay surgery. 2. Translate the HA-binding technology to preclinical joint models of post-traumatic osteoarthritis. The one-step injection of the HA-surface binding technology will be tested in a model of a common meniscal injury where osteoarthritis develops without treatment. The ability of the technology to reduce the progression, prevent, and treat osteoarthritis caused by joint destabilization will be determined.


Descriptors :   CARTILAGE , Joints (Anatomy) , Arthritis , proteins , molecules , lubrication , therapeutics


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE