Accession Number : AD1009533


Title :   DNA Vaccine Electroporation and Molecular Adjuvants


Descriptive Note : Journal Article


Corporate Author : USAMRIID Frederick United States


Personal Author(s) : Suschak,John J ; Schmaljohn,


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1009533.pdf


Report Date : 16 Mar 2016


Pagination or Media Count : 14


Abstract : To date, there is no protective vaccine for Ebola virus infection. Safety concerns have prevented the use of live-attenuated vaccines, and forced researchers to examine new vaccine formulations. DNA vaccination is an attractive method for inducing protective immunity to a variety of pathogens, but the low immunogenicity seen in larger animals and humans has hindered its usage. Various approaches have been used to improve the immunogenicity of DNA vaccines, but the most successful, and widespread, is electroporation. Of increasing interest is the use of molecular adjuvants to produce immunomodulatory signals that can both amplify and direct the immune response. When combined, these approaches have the possibility to push DNA vaccination into the forefront of medicine.


Descriptors :   viruses , Vaccines , DEOXYRIBONUCLEIC ACIDS , immunization


Distribution Statement : APPROVED FOR PUBLIC RELEASE