Accession Number : AD1009502


Title :   A Phase-1 Clinical Trial of a DNA Vaccine for Venezuelan Equine Encephalitis Delivered by Intramuscular or Intradermal Electroporation


Descriptive Note : Journal Article - Open Access


Corporate Author : USAMRIID Frederick United States


Personal Author(s) : Schmaljohn, Connie S ; Dupuy,Lesley C ; Hannaman,Drew ; Ellefsen,Barry


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1009502.pdf


Report Date : 25 May 2016


Pagination or Media Count : 27


Abstract : Venezuelan equine encephalitis virus (VEEV) is a mosquito-borne alphavirus, which causes periodic epizootics in equines and is a recognized biological defense threat for humans. There are currently no licensed vaccines against VEEV available in the United States. We developed a candidate DNA vaccine expressing the E3-E2-6K-E1 genes of VEEV (pWRG/VEEV) and performed a Phase 1 clinical trial to assess safety, reactogenicity, tolerability, and immunogenicity.


Descriptors :   CLINICAL TRIALS , VACCINES , INTRAMUSCULAR INJECTIONS , HUMANS , viruses


Subject Categories : Pharmacology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE