Accession Number : AD1008299

Title :   Quantification of VX Nerve Agent in Various Food Matrices by Solid-Phase Extraction Ultra-Performance Liquid ChromatographyTime-of-Flight Mass Spectrometry

Descriptive Note : Technical Report,01 Oct 2014,01 Jun 2015

Corporate Author : Army Edgewood Chemical Biological Center Aberdeen Proving Ground

Personal Author(s) : Bae,Sue Y ; Winemiller,Mark D

Full Text :

Report Date : 01 Apr 2016

Pagination or Media Count : 26

Abstract : Liquid chromatographyelectrospray ionization mass spectrometry with positive-ion modes of operation were used for the trace-level determination of O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate (VX) in various food matrices. The mixed-mode cation exchange (MCX) sorbent and Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) methods were used for extraction of VX from food samples. The extraction efficiencies obtained with use of the MCX cartridge and QuEChERS methods were compared, and the results revealed that both methods performed similarly. Various VX concentrations, ranging from 5 to 500 ng/mL, were spiked into food samples. The linear range of quantitation for VX was 1 to 330 ng/mL. The total percent recoveries (and percent relative standard deviations) for VX in various food samples are reported.

Descriptors :   liquid chromatography , chemical warfare agents , nerve agents , magnesium compounds , fluoropolymers , electrospray ionization , mass spectrometry , food , hydroxides

Distribution Statement : APPROVED FOR PUBLIC RELEASE