Accession Number : AD1008269


Title :   Treatment of the Cornea Using Transcytotic Delivery into the Tear Film


Descriptive Note : Technical Report,27 Sep 2012,26 Sep 2015


Corporate Author : University of Southern California Los Angeles United States


Personal Author(s) : MacKay,J A ; Wang,Wan ; Edman,Maria C ; Hseuh,Pang-Yu ; Hamm-Alvarez,Sarah


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1008269.pdf


Report Date : 01 Dec 2015


Pagination or Media Count : 220


Abstract : The aim of this study is to develop therapeutics that are retained at the ocular surface and stimulate corneal wound healing using a biodegradable and biocompatible drug delivery platform technology to treat combat-related eye injuries. Utilizing a local delivery approach with direct intra lacrimal injection combined with an unique drug delivery platform, consisting of biodegradable nanoparticles targeted to facilitate uptake into the lacrimal gland, we have been able to form local drug depots in the lacrimal gland. In addition, we have observed transcytosis of related nanoparticles across the polarized lacrimal glandacinar cells. The therapeutic agent used in these studies has a strong prosecretory effect on the lacrimal gland and a mitogenic effect on corneal wound healing. These findings pave the way for a unique strategy of drug delivery to the lacrimal gland and the anterior segment of the eye, enabling a quick treatment promoting wound healing that is sustainable until an injured soldier in the field can reach a hospital setting for further treatment.


Descriptors :   eye diseases , health services , retinal diseases , drug therapy , proteins , Lacrimal glands , Adenoviruses , Cornea


Distribution Statement : APPROVED FOR PUBLIC RELEASE