Accession Number : AD1008253


Title :   ETS Gene Fusions as Predictive Biomarkers of Resistance to Radiation Therapy for Prostate Cancer


Descriptive Note : Technical Report,15 Jul 2010,14 Jul 2011


Corporate Author : The University of Michigan Ann Arbor United States


Personal Author(s) : Feng,Felix


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1008253.pdf


Report Date : 01 Aug 2011


Pagination or Media Count : 29


Abstract : The research goals of this grant proposal are to: 1) investigate the effect of ETS gene fusions on radiation phenotype in preclinical models of prostate cancer, 2) to explore the mechanism of interaction between ERG (the predominant ETS gene fusion product) and the DNA repair protein DNA-PK, and 3) to determine if ETS gene fusion status is a clinical biomarker ofradio resistance for prostate cancer. The training goals of this grant proposal included a series of regular meetings with mentors, research seminars, journal clubs, and workshops, all of which are intended to help Dr. Feng develop as a translational scientist. This grant proposal was approved as a five-year award; the current annual report summarizesaccomplishments over the first year of the grant, from July 15, 2010 to July 15, 2011.


Descriptors :   prostate cancer , genes , radiation , therapy , RADIATION RESISTANCE


Distribution Statement : APPROVED FOR PUBLIC RELEASE